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UID:sabre-vobject-193b95a4-c5fa-49ac-aeb8-fc2802c78103
DTSTAMP:20260509T103557Z
SUMMARY:Next Generation Environmentally Friendly Antibiotics
DESCRIPTION:Resistance to antibiotics is a severe problem in contemporary m
 edicine. Many antibiotics inhibit protein biosynthesis by hampering the ri
 bosome function. Structures of bacterial ribosomes in complex with these a
 ntibiotics illuminated common pathways of antibiotics inhibitory action\, 
 but not the species-specific diversity in infectious-diseases susceptibili
 ty. Recent structural studies on ribosome from a multi-resistant pathogeni
 c bacterium and careful comparisons to ribosomes from non-pathogenic bacte
 ria revealed novel structural motifs\, essential to protein biosynthesis b
 ut not located in the primary ribosomal active sites\, hence no mechanism 
 for modification leading to resistance of these sites is currently known. 
 These led to the design of antibiotics with desired properties that can be
  optimized in terms of their chemical properties\, toxicity and penetratio
 n\, alongside species-specificity\, thus preserving the microbiome\, as we
 ll as in terms of bio degradability\, thus reducing the ecological hazards
  caused by the spread of the current antibiotics’ metabolites.Leopoldina
  Lecture by Nobel Laureate Prof. Dr. Ada Yonath The event is open to all i
 nterested parties.
DTSTART;TZID=Europe/Berlin:20190612T180000
DTEND;TZID=Europe/Berlin:20190612T200000
LOCATION:Robert-Koch-Platz 7 \, Berlin (Deutschland) 
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DESCRIPTION:Next Generation Environmentally Friendly Antibiotics
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